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KMID : 0357919840180040425
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Korean Journal of Pathology
1984 Volume.18 No. 4 p.425 ~ p.431
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Ultrastructural Observation on Melanosis Coli
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Abstract
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Histochemical and ultrastructural observations were carried out on pigments in
melanosis coli from a 71 years old male who has taken laxatives (laxenta and dulcolax)
for 3 years and received a left hemicolectomy on adenocarcinoma of the descending
colon. The pigments were confined within the lamina propria of entire non-neoplastic
colonic mucosa and showed histochemical reactions similar predominantly to lipofuscin
but with partial overlapping with those in melanin pigments. Ultrastructurally, the
denatured mitochondria and endoplasmic reticulum were demonstrated within the
pigmented granules and in the macrophages to suggest that pigments are of lipofuscin
derivatives which originate from the denatured lipoprotein membranes of cytoplasmic
organelles of injured colonic epithelial cells.
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